Secretory cells in glands and the nervous system frequently package and store proteins destined for regulated secretion in dense-core granules (DCGs), which disperse when released from the cell surface.Despite the relevance of this dynamic process to diseases such as diabetes and human neurodegenerative disorders, our mechanistic understanding is r
BackgroundImmune check Cable Ties point inhibitors (ICIs) are standard treatment for patients with non-small cell lung cancer (NSCLC).Nearly a decade has passed since nivolumab was approved by the FDA for NSCLC patients.However, long-term outcomes and clinical features remain unclear for individual cases.Pseudo-progression is a well-known paradoxic
We consider the problem of constructing generic supporting hyperplanes Statues to be used within a (branch and) bound-and-cut algorithm.We review some of the properties that these hyperplanes should enjoy.It is generally admitted that they should cut a parasitic point generated during the process.We argue that the advantages of restricting supports